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Pandey, S. N.
- Antibiotics Induced Adverse Drug Reaction Monitoring in a Teaching Hospital in Chhattisgarh
Authors
1 Chhattisgarh Institute of Medical Sciences, Bilaspur, Chhattisgarh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 1 (2012), Pagination: 13-16Abstract
Aims- The Aims of this study were:
(a) To evaluate antibiotic exposure in inpatients in medicine departments of CIMS hospital.
(b) To determine the frequency of medication-related events;
(c) To characterize the types of ADR observed.
Material and Methods- A prospective, reporting study was conducted over a period of 6 months of inpatient admissions in the medicine departments of a teaching government hospital. The data of all inpatients undergoing antibiotic treatment were collected by our trained team and validated by an expert panel. Data were recorded on pre-formatted forms.
Results- Of the total of 1600 patient, analyzed 1300 adults (46%male 54% female) 300 children (50% male, 50% female). ceftriaxone (36%) was the most widely used antibiotics, cefotaxime 25%), inj ampicillin (16%) ofloxacin 10% amikacin 6%, gentamicin 6%, ciprofloxacin 5%, piperacilline+toza 2%. Out of 1600 patient, Adverse drug reaction were reported in 66 patient Drug cefotaxime developed leucopenia 7 days after therapy.
Drug ofloxacin developed life threatening complications (rashes, urticaria, perspiration) in 12 patients, later 10 patient detoriorated with shock and non recordable bp/pulse. Shifted to emergency ward.
After ciplox 10 adult patient and 2children developed skin rashes and urticaria along with gastro enteric disease. Amikacin given resulted after 3 days into renal changes and Later after 3 days resulted in raised urea and creatinine. Same adverse effect was seen with 3 patient with gentamicin. Piperacillin and Toza resulted with life threatening reaction i.e. angio neurotic edema and hypertension.
Conclusions- Hospital based monitoring is a good method with which to detect known and unknown links between drug exposure and ADRs. The clinicians should make an attempt for early detection and be vigilant about safety profile monitoring of the prescribed medications.
References
- Salama S, Rotstein C, Mandell A. A multidisciplinary hospitalbased antimicrobial use program: impact on hospital pharmacy expenditures and drug use. Can J Infect Dis 1996;7:104-9.
- Mazzeo F, Capuano A, Motola G, Russo F, Berrino L, Filippelli A, et al. Antibiotic use in an Italian university hospital. J Chemother 2002;14:332-5.
- Vlahovic-Palcevski V, Morovic M, Palcevski G. Antibiotic utilizationat the university hospital after introducing an antibiotic policy. Eur J Clin Pharmacol 2000;56:97-101.
- Thurmann PA. Methods and systems to detect adverse drug reactions in hospitals. Drug Saf 2001;24:961-8.
- Otero Lopez MJ, Dominguez-Gil A. Acontecimientos adversos por medicamentos: una patologia emergente.
- R. Arulmani SD Rajendra and B Suresh Adverse drug reaction monitoring in a secondary care hospital in South India. British journal clinical Pharmacology. Med. Feb 2008 V. 65(2).
- Wills s brown D.A proposed new means of classifying adverse drug reaction to medicines, pharm.j.1999;262:163-5.
- Hartwig sc, siegelj,Schneider pj. Preventability and severity assessment in reporting adr. Am.j. hosp pharm. 1992;49:2229-32.
- Pir mohammed et al 2000 adverse drug reaction. Br. Med.jr. 318; 1295-98.
- A.P. Gor, S.V. Desai. Adverse drug reaction (ADR) in the in patient of Medicine Department of a rural Tertiary care teaching hospital and influence of pharmacovigilance in reporting ADR indian I pharmacology. Med. Feb 2008; Vol 40; issue 1; 37-40.
- Eileen g, hollcend, phevmd. And frank.v. degrig m.d. drug induced disorder D. family physician November 1997; 2:10.
- Filomena Mazzeo, Annalisa Capuano, Analia Avolio, Amelia filippelli, Franciso Rossi. Hospital based intensive monitoring of antibiotic induced adverse events in a university hospital. Pharmacology research. Med : 51 (2005) 269-274.
- Determinants in Short Term Prognosis of Acute Myocardial Infarction (in 125 Cases without Intensive Coronary Facilities)
Authors
1 Department of Medicine, M. L. N. Medical College, Allahabad, (U.P.), IN
Source
The Indian Practitioner, Vol 32, No 7 (1979), Pagination: 389-396Abstract
No Abstract.- Estimation of Groundwater Recharge Potential of Domagor-Pahuj Watershed Using Water Table Fluctuation Method
Authors
1 Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia-741 221, West Bengal, IN
2 Deptt. of Farm Engineering, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi-221 005, U. P., IN
3 National Research Centre for Agroforestry, Jhansi-284 003, U.P., IN
4 International Crops Research Institute for the Semi-Arid Tropics, Patancheru, Hyderabad-500 231, Andhra Pradesh, IN
5 Jhansi-284 003, U. P., IN
Source
Nature Environment and Pollution Technology, Vol 14, No 1 (2015), Pagination: 125-128Abstract
Groundwater is one of the important sources of potable water. The water table fluctuation method was used to evaluate the annual variations in water level rise and to estimate the groundwater recharge during pre interventions and post interventions phase of Domagor-Pahuj watershed development. The area experiences an average annual rainfall is 880 mm. The estimates of average annual water table fluctuation and change in groundwater storage volume of randomly selected thirty wells of pre-interventions and post-interventions phases of watershed were 3.03 to 4.34 million m3, and 1.52 to 2.18 million m3, respectively. The total annual groundwater recharge potential estimated for the areas was 1.47 million m3 before intervention and 2.06 million m3 after intervention.Keywords
Groundwater Recharge, Infiltration Factor, Specific Yield, Water Level Fluctuation, Watershed.- Superconductivity and Superfludity Once Again at the Highest Level: Nobel Prize in Physics 2003
Authors
1 Dept. of Physics, Sant Longowal Inst of Engg. & Tech Dt. Sangrur. Punjab, IN